NEURO410 Lecture Notes - Lecture 17: Hypokinesia, Essential Tremor, Putamen
12 Oct 2016
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Lecture 6: clinical features and treatment of pd (march 10 / 16) Illustrate clinical features of atypical and typical pd. Emphasizing risk factors and management of dementia in pd. Tremor: when most relaxed (distinguishes it from essential) Rigidity: stiffness the dr feels in examination (fixed resistance to movement of a limb) Dramatic improvement in response to da = clue that it is pd; plasticity da excessive moving. Cholinergic neuron loss is as profound as or more profound than ad. Multiple changes: nt changes (mainly da + others) and systems denervate. Widespread lewy body changes: correlates well with cognitive disability. May notice that their hand writing increasingly gets slower (not usually quantify speed but size) Smell loss: clue (recall other conditions) do not have smell loss; olfactory change, not nt. Rem sleep behaviour disorder: rem normally suppress all movement; in pd, this suppression is affected; about 50% can thrash, talk, move (not perfect clue)
