MMI133 Lecture Notes - Lecture 11: Anaphylatoxin, Mast Cell, Vascular Permeability

• School: University of Alberta
• Department: Medical Microbiology and Immunology
• Course: MMI133
• Professor: Judy Gnarpe

Document Summary

Loss of fxn of affected part (later addition) A reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues (cid:894)su(cid:271)sta(cid:374)(cid:272)e (cid:373)o(cid:448)i(cid:374)g out of bv = glue = i(cid:374)fla(cid:373)(cid:373)ator(cid:455) e(cid:454)udatio(cid:374)(cid:895) Both open up blood vessel slowing down flow of blood, making it easier for wbcs to stick to walls and sneak out. Are family of molecules, made by membrane lipids on cells. If have ab molecule that catches an ag conformational change enzyme cascade. Acts via diff r in periphery to cause little blood vessels to open up. Lot less spe(cid:272)ifi(cid:272); (cid:271)od(cid:455)"s (cid:449)a(cid:455) to figure out if so(cid:373)ethi(cid:374)g (cid:271)ad is o(cid:272)(cid:272)urri(cid:374)g (ie bacterial polysaccharides from cell walls/capsule) Complement = like symphony orchestra; family of proteins. Acts like histamine: stretches apart endothelium and moves bv apart. Complement ie c5a will go to site of bacterial infection. Oxidative killing: ie pokes holes and then pour in bleach (hypochloride ion)