MMI133 Lecture Notes - Lecture 10: Anaphylatoxin, Vascular Permeability, Mast Cell

• School: University of Alberta
• Department: Medical Microbiology and Immunology
• Course: MMI133
• Professor: Judy Gnarpe

Document Summary

Malaise with ague central abdominal pain for 24 hours. Severe right lower quadrant pain for 4 hours. > had to get his appendix removed after today, you"ll be able to discuss: The microscopic changes which occur in in amed tissues. The cellular and molecular mechanisms behind these changes. A reaction of the microcirculation characterized by movement of uid and leukocytes from the blood into extravascular tissues. Serotonin (platelets) (causes little peripheral blood vessels to open up) The classical pathway -> certain antibodies, like igm . (antibodies) The alternative pathway -> bodies way to guring out his something is wrong, things will set this off is just bacterial polysaccarides, it aggregates if u have complement the white blood cells will blow themselves apart. Anaphylotoxin (mast cells, vessels) > acts like histonine, stretches out molecule. Target cell lysis (membrane perforation) -> last components of complement will set off c9 to polymerize that will punch a hole in target cells neutrophils.