BIOL207 Lecture Notes - Lecture 3: Archibald Garrod, Arginine, Wild Type

• School: University of Alberta
• Department: Biology (Biological Sciences)
• Course: BIOL207
• Professor: John Locke

Document Summary

Lecture 3 genes, biological pathways, and 1 gene: 1 enzyme. Required readings and problems: open genetics lectures chapter 3. 9th ed. pp 230-235, problems: chapter 6: 1-7, 25, 28, 50 http://www. dnalc. org/view/16360-animation-16-one-gene-makes-one-protein-. html. Concept 17. 1: a mutation in a gene changes in a protein changes in a phenotype. Leads to one gene: one enzyme hypothesis: work of beadle and tatum arginine mutations in neurospora, mutation in different genes can be identified by location and phenotype. Also: dna sequences specifies the structure of proteins. Gene protein function phenotype: early in last century 1902, human hereditary defects were due to defects in basic body biochemistry. (cid:374)ow (cid:272)alled (cid:862)i(cid:374)(cid:271)or(cid:374) errors i(cid:374) (cid:373)eta(cid:271)olis(cid:373)(cid:863) genes enzymes metabolism. Focused attention on the metabolic control by genes. Macromolecules are synthesized in a series of biochemical steps. If we inactivate (mutate) one gene for e(cid:454)a(cid:373)ple: ge(cid:374)e (cid:862)(cid:271)(cid:863) i(cid:374) o(cid:374)e strai(cid:374) of orga(cid:374)is(cid:373) In that strain, no b enzyme cannot carry out 2 3 conversion.