NURS 3550H Lecture Notes - Lecture 7: Angina Pectoris, Propranolol, Prazosin
28 Dec 2018
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Document Summary
Alpha antagonists: block alpha1-receptors and alpha2-receptors limited uses d/t reflex tachycardia. Alpha1 antagonists: selective alpha blockers, prazosin in seminar. Alpha2 antagonists limited uses: severe reflex tachycardia. Beta antagonists: non-selective, selective, block beta1 and beta2 receptors, some also block alpha1 receptors, block beta1 receptors, desired impact, some also block alpha1 receptors. Mechanism: block beta1 and beta2 receptors, benefits = Therapeutic indications: cardiac dysrhythmias, angina pectoris, myocardial infarct, heart failur3, hypertension. Non-cardiac therapeutic indications: migraine, performance anxiety, hyperthyroidism, glaucoma, pheochromocytoma. Adverse effects: bradycardia, reduced cardiac output, precipitate heart failure, heart block, exercise intolerance, confusion, nightmares, depression, hypoglycemia, bronchoconstriction. Contraindications: depression, bradycardia, av block, heart failure, severe allergy, cautions reduced renal output, asthma, diabetes. Interactions: antihypertensives, drugs affecting cardiac rhythm, albuterol. Beta antagonists: no abrupt withdrawal, best choice is beta1 selective antagonist. Effects: dec hr and contractility, dec renin release, dec bp. Adverse effects: bradycardia, reduced cardiac output, precipitate heart failure, heart block, exercise intolerance, very rare, confusion, nightmares, depression, hypoglycemia, bronchoconstriction.
