BIOL 1550 Lecture Notes - Lecture 4: Cytochrome P450, Drug Metabolism, Metabolite
Document Summary
Enzymatic alteration of drug molecule goal = to increase polarity (charge) or size commonly called. Metabolism in order to enhance excretion of drug. Enzyme changes chemical structure of drug: product = Main organ: good hepatic function, key in proper clearance of drugs. Usually carried out by enzymes: drug metabolizing enzyme (dme) One dme : based on role of enzymes? role of dmes, change drug to, make drug large and/or charged to. Variety of different dme systems: most common = hepatic microsomal enzyme system, cytochrome p450 system. Cyp family: 12 related families of dmes. Carry out specific phase 1 reactions: cyp1, cyp2, cyp3 metabolize drugs. Cyp 3a4, cyp 2d6: specific d is target of specific cyp. Can determine which dme will affect a drug. Dme reactions either phase 1 or phase 2: specific to each phase, variety of dme"s, drug metabolized by. Many phase 1 enzymes exist: cyps - phase 1 reactions increases excretion.