MBB 463 Lecture Notes - Lecture 15: Macular Degeneration, Heritability, Dna Profiling
19 Aug 2020
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Info on whether you have a variant that can lead to a specific disease. Looking at snp (single nucleotide polymorphisms: variation in a single base in the dna, typically bi allelic (only 2 options, usually in non-coding region, not translated into a gene. If coding, still may not change amino acid sequence of the protein: ~1 in 1000bp/person, considered a snp if occurs in 1% or more of the population. Limited by definitions of ancestry/ethnicity: dna doesn"t have borders, categorial bias of study design. 23 and me and ancestry: 23 and me, founded in 2006, valued at over 1 bill, yikes !! issues with fda bc was giving health info. Initially, reported 240 health conditions: now only 10 and fda approved, snps determined by microarray. Look closely: we also excluded individuals that were not of european. Implications: uses snps instead of strs for individuation, dna profiling services for forensic investigation.
