HSCI 216 Lecture Notes - Lecture 2: Epigenetics, Human Genome, Tortoiseshell
20 May 2020
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Tuesday, may 19, 2020: human genome sequence composed of 4 letters repeated times (3000 mil from each parent) Just 1 that"s wrong can be devastating disease. Epigenetic phenomena: genetic identity does not equal phenotype identity. Eg. inbreeding mice with identical conditions: mice are not identical, vary in things like bodyweight. Eg. maggot vs fly: have same genetic code. Eg. crocodiles: dna sequence same in both genders, epi means "add on" to genetics. How can a single dna genome code for multiple outcomes: dna is a script, not a template (you can edit a script - ie sticky notes, pencil notes, different cells/organisms must use the same script in different ways. Epigenetic modifications: change likelihood of gene expression but not the sequence. Example: rat babies being licked by mothers or not: fat yellow nice vs brown small mice identical dna sequence, after giving alcohol their offspring different. Epigenetic info is passed on from parent to child.
