BISC 313 Lecture Notes - Lecture 3: Hepatocyte, Xenobiotic, Toxicant

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turquoisescorpion358

4 Oct 2020

School

Simon Fraser University

Department

Department of Humanities Biological Sciences

Course

BISC 313

Professor

Vicki Marlatt

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Document Summary

Pathway to showcase the end results of the toxicant. Liver has pigments, hepatocytes, and sinusoids in their tissues: power houses for detoxification & metabolism (hepatocytes, detox enzymes. Ecotoxicological effects assessment (similar principles also apply to human toxicological effects) Combination of analysis and inference of possible consequences of the exposure to a particular agent based on knowledge of the dose-effect relationship with that agent in a particular organism, system or (sub) population. ** reason why years of research is required b/c need to understand what the normal behaviour of the animals are to pinpoint if there is an adverse effect. Conservation of many biomolecules and organs among vertebrates, and even some across invertebrate and vertebrate taxa. Some extrapolation uncertainty between organisms: must have good knowledge of the organisms in order to extrapolate data from one organism to another (i. e. functions/ components of liver) Ecotoxicology effects analysis: e. g. of endpoints >/= population level.

Related Questions

[email protected]

Tue 9/19/2017 4:17 PM

To:

[email protected];

Here is the exam review for our next major lecture exam which will be on Monday. Notice that there are a few things missing, such as endochondral ossification. These will be added so just because it does not show up on this exam review doesn't mean you shouldn't study it. That being said, the details of each and every bone which I've gone over in lecture will be on the lab practical rather than the written lecture exam.

Anat 1, Exam 2. Spr 2016 LASC Name:____________________________________________________

1) A synarthrosis: a) is filled with synovial fluid. b) allow for a wide range of movement. c) includes the squamosal suture. d) is exemplified by the shoulder. e) all of the above.

2) Bursae: a) are located in the right atrium. b) are like elastomeric shock absorbers. c) are found in skeletal muscle fibers. d) form the sarcoplasmic reticulum. e) none of the above.

3) Irregular bones: a) can act like cams. b) can provide sites for muscle attachment. c) can protect soft-tissue organs. d) can act as levers. e) all of the above.

4) Condyles: a) are smooth articular surfaces. b) allow blood vessels to enter the bones. c) occur beneath the nail body after an injury. d) are produced by infected sebaceous glands. e) none of the above.

5) A head: a) is where you will find hyaline cartilage. b) is a smooth articular surface. c) is where a bone meshes with another bone. d) all of the above. e) none of the above.

6) Which of the following is the proper sequence of things following a bone fracture: a) hematoma, fibrous callus, bony callus, remodeling. b) hematoma, bony callus, fibrous callus, remodeling. c) hematoma, remodeling, fibrous callus, bony callus. d) hematoma, remodeling, bony callus, fibrous callus. e) fibrous callus, bony callus, remodeling, hematoma.

7) A diaphysis: a) contains yellow bone marrow. b) contain a lot of spongy bone tissue. c) occurs at the ends of long bones. d) all of the above. e) none of the above.

8) Short bones: a) protect underlying soft tissue organs. b) include the ribs. c) include the cranial bones of the skull. d) transfer mechanical forces. e) all of the above.

9) Fibrous joints: a) contain cruciate ligaments. b) include the pubic symphysis. c) are typically found in third class levering systems. d) include the lambdoid suture. e) all of the above.

10) Which of the following doesnât belong? a) tibiofibular joint. b) dentino-alveolar joint.
c) intervertebral disc. d) radioulnar articulation. e) cartilage.

11) Which of the following doesnât belong? a) atlanto-occipital joint. b) humero-ulnar joint. c) frontal suture d) acromio-humeral joint. e) tibiotarsal joint.

12) Hyaluronic acid: a) forms the extracellular matrix. b) is found in fibrous joints. c) keeps cartilage soft and pliable. d) is found in synostoses. e) none of the above.

13) First class levers: a) include the tibio-tarsal joint. b) have the effort between the fulcrum and the load. c) are like a teeter-totter. d) all of the above. e) none of the above.

14) Synchondroses: a) are typically synovial joints. b) allow for very limited movement. c) include sutures and gomphoses. d) are encased in synovial capsules. e) none of the above.

15) Parallel muscles: a) have long excursions. b) include the abdominal muscles. c) have excellent endurance. d) have low strength. e) all of the above.

16) Sphincteral muscles: a) enclose openings or passageways. b) are used when you talk.
c) surround the eyes. d) include the orbicularis oculi. e) all of the above.

17) Pennate muscle architecture: a) is typified by the pectoralis major. b) have high endurance.
c) generates high strength. d) has a longer excursion. e) all of the above

18) Endomysium: a) consists of dense fibrous connective tissue. b) surrounds each fasciculus.
c) surrounds bundles of muscle cells. d) all of the above. e) none of the above.

19) Cartilage: a) heals quickly if it is damaged. b) forms the lining of blood vessels. c) is found on the articular surfaces of bones. d) is a type of epithelial tissue. e) none of the above.

20) A tuberosity: a) is a hollow opening. b) is a shallow smooth articular surface. c) is a raised area that adjoins a condyle. d) is a larger outwardly curved articular surface. e) is a raised, rough-textured area.

21) Which of these doesnât belong? a) tuberosity b) trochanter c) condyle d) tubercle e) lunula

22) Epimysium: a) wraps around the entire muscle. b) is made of dense fibrous connective tissue. c) is continuous with tendons. d) all of the above. e) none of the above.

23) Which of the following is more likely to be an insertion rather than an origin? a) ulna.
b) cervical vertebra. c) thoracic vertebra. d) rib. e) Ischium.

24) Which of the following is more likely to be an origin rather than an insertion? a) clavicle.
b) tibia. c) radius. d) ulna. e) metatarsal.

25) Myofibrils: a) are composed of many muscle fibers. b) are composed of many muscle cells.
c) are composed of many sarcomeres. d) form the endomysium. e) all of the above.

26) Myosin: a) helps keep muscle cells from overstretching. b) is a protein. c) joins thin filaments together. d) forms part of the z-disc. e) all of the above.

27) Sarcolemma: a) surrounds the entire muscle organ. b) surrounds the endomysium.
c) is the cell membrane of a muscle fiber. d) surrounds the epimysium. e) none of the above.

28) Thin filaments: a) are made of titin. b) are pulled on by the thick filaments during contraction.
c) create the molecular âpower-strokeâ. d) all of the above. e) none of the above.

29) A second class lever: a) is like a wheel barrow. b) is like a teeter-totter. c) describes the humeroulnar joint. d) describes the atlanto-occipital joint. e) none of the above.

30) A sarcomere: a) is the basic unit of muscle function. b) is made mostly of proteins. c) shortens during a contraction. d) delivers an âall or noneâ response. e) all of the above.

31) Fast glycolytic fibers: a) have excellent endurance. b) deliver lots of power.
c) are more reddish in color than oxidative fibers. d) none of the above. e) all of the above.

32) Which of the following doesnât belong? a) Vastus lateralus. b) Vastus intermedius. c) Vastus medialis. d) Rectus Femoris. e) Gluteus minimus.

33) Which of the following doesnât belong? a) Teres major. b) Teres minor. c) subscapularis.
d) infraspinatus. e) supraspinatus.

34) Tendon sheaths: a) are filled with synovial fluid. b) can be likened to brake and shifter cable sheathing on a bike. c) are found around the carpal bones. d) really make life unpleasant if they get inflamed. e) all of the above.

35) Epithelial tissues: a) function in movement. b) conduct electrical impulses. c) form a structure for attachment of other organs. d) form barriers and walls. e) all of the above.

36) Elastic connective tissue: a) is found in bone. b) lines the inside of the trachea. c)Is found in small blood vessels like capillaries. d) is found in large arteries. e) all of the above.

37) Cartilage: a) heals quickly if it is damaged. b) forms the lining of blood vessels. c) is found on the articular surfaces of bones. d) is a type of epithelial tissue. e) none of the above.

38) Dense regular connective tissue: a) is poorly vascularized. b) heals slowly if at all. c) forms tendons and ligaments. d) can look a lot like smooth muscle under the microscope. e) all of the above.

39) Transitional epithelium: a) lines the urinary bladder. b) lines the blood vessels. c) contains cilia. d) joins the epidermis to the dermis. e) none of the above.

40) Skeletal muscle: a) responds to conscious thought. b) is found in the heart. c) is found in the walls of blood vessels and the GI tract. d) is composed of very small cells. e) all of the above.

For the following matching questions, each choice is used only once.

41) Fibroblast a) maintains bone tissue
42) Mast Cell b) secretes mucus
43) Chondrocyte c) responsible for inflammation response
44) Osteocyte d) makes collagen fibers
45) Goblet Cell e) maintains cartilage

For the following true-false questions, mark âAâ for true and âBâ for false.

46) Simple cuboidal epithelium is lines the trachea and Fallopian tubes/oviducts.
47) Elastic cartilage joins the ribs to the sternum.
48) An insertion is the more movable point of muscle attachment.
49) Tendons connect muscle to muscle or bone to bone.
50) Ligaments connect muscle to bone.
51) Transverse tubules allow nutrients to be dispersed throughout very large muscle cells.
52) Muscle twitch occurs when only a few muscle cells in the entire muscle are fully contracted.
53) Slow oxidative fibers have poor strength but excellent endurance.
54) Muscles can lengthen under their own power as well as contract.
55) Pottâs fracture is typical of skateboarders.
56) An incomplete fracture is a complete break through the entire bone.
57) Tetanus is the recruitment of additional fibers during muscle contraction.
58) Menisci are like elastomeric shock absorbers.
59) Diarthrotic joints allow for little to no movement.
60) A belly is the contractile portion of a muscle.
61) Synergistic muscles work with each other.
62) Muscle tissue, like your lab instructorâs evil twin before his morning coffee, is irritable.

redbutterfly464

1. If given a biological question, demonstrate your ability to scientifically analyze the problem2. How does the scientific method work?3. How are clinical drug tests conducted?4. What is natural selection, how does it work, and how does it compare to artificial selection?5. How did the ideas of Lamarck differ from those of Darwin?6. What evidence is there for evolution?7. Give examples of homologous/vestigial structures and atavisms8. What is the importance of the Hardy Weinberg equilibrium and how may it be violated?9. What are the effects of different forms of natural selection?10. How does one construct and read a cladogram?11. How does speciation occur?12. What are different types of reproductive isolating mechanisms?13. What are the types of14. What are major events in the evolution of life and when did they occur?15. What is the basic structure of different types of prokaryotes?16. How does this structure prevent cell lysis?17. How does the arrangement of genetic material allow for rapid reproduction in prokaryotes; how do they maintain genetic diversity?18. What are the Archaea and where are they found?19. What is the theory of endosymbiosis? What is secondary endosymbiosis?20. What are characteristics of the major groups of Protista discussed in class?21. Why is the kingdom Protista not a valid kingdom?22. How does one tell a plant from algae?23. How does the moss life cycle differ from that of other plants?24. How are ferns better adapted to life on land than mosses? How are they still tied to the water?25. What are the major groups of seed and seedless plants discussed in class and how are they different?26. What is the basic plant life cycle?27. Where do plants make sperm and eggs?28. Who are the major groups of seed plants, do any have swimming sperm?29. What benefits do seed plants have over ferns in terms of life on land30. What benefits do flowering plants have over gymnosperms?31. In what ways are angiosperms affected by coevolution with pollinators and herbivores?32. Where are the gametophytes found in seed plants?33. How does sperm get to the egg in seed plants?34. How do wind and animal pollinated flowers differ?35. How do fungi obtain their nutrients?36. In what ways do fungi interact with their environment?37. How do mushroom producing fungi reproduce?38. How do fungi benefit and otherwise affect humans?39. What are traits shared by all animals?40. What are major distinguishing traits of the phyla discussed in biology 2 lecture?Which groups are bilateral etc.41. What groups have parasites or other disease causing organisms?42. Why are arthropods so successful?43. What are traits of Chordates?44. Describe the adaptations to life on land, how do they parallel those seen in plants?45. What makes us Human?46. How is a bird adapted for flight?47. How does available surface area influence fungi, plants and animals?48. What was the significance of van Helmont

rosehornet110

This includes showing all calculations and explaining why you selected a specific answer for each multiple choice question (i.e. donât just circle the correct answer). I am looking to see how you got the answer, not just that you have the correct answer.

Below is data from the United States Cancer Statistics about the number of news cases of lung cancer in males in the U.S. for 2011 for ages 30 and older.

Table 1: U.S. Population Size and Incidence Cases of Lung Cancer in Males for 2011

Age (Years)	U.S. Male Population	White Population	White Incidence Cases	Black Population	Black Incidence Cases
30-34	10,181,564	7,950,924	88	1,383,650	22
35-39	9,666,162	7,557,263	212	1,271,897	23
40-44	10,363,126	8,259,215	643	1,324,847	132
45-49	10,856,131	8,766,225	2,032	1,373,346	444
50-54	10,976,172	9,004,383	5,128	1,329,551	1,148
55-59	9,733,849	8,101,629	8,607	1,091,030	1,687
60-64	8,466,308	7,183,960	12,340	845,362	2,067
65-69	6,014,777	5,178,255	15,792	539,796	2,077
70-74	4,360,942	3,769,569	16,011	376,129	1,864
75-79	3,204,196	2,807,216	14,319	255,221	1,426
80-84	2,319,839	2,078,071	11,284	154,155	883
85+	1,873,942	1,688,433	7,616	117,267	545
Total	88,017,008	72,345,143	94,072	10,062,251	12,318

3. What is the age-specific incidence rate for lung cancer in white men age 75-79 for 2011?(1 pt)

0.005 per 1000

1.3 per 1000

1.2 per 1000

5.1 per 1000

5.6 per 1000

F. Cannot be calculated from the given information

4. What is the age-specific incidence rate for lung cancer in black men age 75-79 for 2011? (1 pt)

0.005 per 1000

1.3 per 1000

1.2 per 1000

5.1 per 1000

5.6 per 1000

F. Cannot be calculated from the given information

Questions 5 through 7 are based on the information below:

Using the information in Table 1, researchers calculated the crude incidence rates and age-adjusted incidence rates (via the direct method) for both groups.

Table 2: Crude incidence rates and age-adjusted incidence rates for white and black males

White Males		Black Males
Crude Incidence Rate	Age-adjusted Incidence Rate	Crude Incidence Rate	Age-adjusted Incidence Rate
1.3 per 1000	1.2 per 1000	1.2 per 1000	1.5 per 1000

5. True or False, there is likely a difference in the age composition between the white and black males. Explain your answer

6. Based on the information in Table 2, it was reported that there was an increased risk of lung cancer in black males in 2011. (1 pt)

The conclusion is:

Correct, the age-adjusted rate is higher in black males compared to white males

Correct, because both the crude and age-adjusted rates are higher in black males compared to white males

Incorrect, because the incidence rate for white males is actually higher than the incidence rate for black males

7. What type of age-adjusted rate was calculated in table 2? How does it differ from the age-adjusted rate in question 5 in the in-class exercise for age-adjustments? Hint: See slide title: Adjustments for Other Measures of Disease Frequency in the lecture title Adjusted Rates (1 pt)

Question 8 is based on the information given below:

Cause-specific mortality rates for men in 2010 in the U.S. from various types of cancers are shown in the table below:

Cause-Specific Mortality Rates

(per 100,000 Men)

Location of the Cancer

in the Body White Asian

Pancreas 13.2 5.7

Prostate 19.1 2.5

Lung 62.3 18.5

Skin 4.9 0.3

8. The inference that White men in the U.S. are at higher risk of death due to cancer of the pancreas, prostate, lung, and skin compared to Asian men in the U.S. is

A. correct

B. incorrect because of failure to determine cause-specific mortality rates

incorrect because proportionate mortality alone does not give an estimate of risk

D. incorrect because of failure to adjust for differences in the age composition of the two populations

E. incorrect because counts were used when cause-specific mortality rates were needed

9. In January 1996, a team of epidemiologists identified a sample of 4,500 men, 65-74 years of age, for a study of prostate cancer. Tests indicated that 315 of the men already had prostate cancer and, therefore, were not at risk. The rest of the men were followed prospectively for five years to determine the incidence rate of prostate cancer in the sample. By the end of the five years of follow-up 156 of the men had developed prostate cancer. What is the incidence rate of prostate cancer in this group?

10. An epidemiologic investigation that started on January 1, 2011, identified a population of 1,000 individuals. At the start of the study 4 were found to have the disease. During the year of study, 6 new cases were found; thus a total of 10 cases were identified. Among those 10 cases, 6 deaths occurred during the year. What was the prevalence of the disease during the 1-year study?

pinkhornet564

BISC 313 Lecture Notes - Lecture 3: Hepatocyte, Xenobiotic, Toxicant

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