BISC 313 Lecture Notes - Lecture 14: Dichloromethane, Toxicokinetics, Particulates
21 Feb 2019
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Absorption: sites of absorption, skin -> physiology/anatomy (understanding the function of these systems and how it relates to uptake) All about transfer + exchange: lungs are built for exchanging gases (eliminate co2 + uptake o2, gas exchange occurs in alveoli. Things that can be taken into the lungs: gases (eg. co, no, vapours (eg. methylene chloride, aerosols (eg. droplets, particulates (solid, eg. dust) X -> low solubility in blood: perfusion-limited uptake. Limited by the blood supply moving by the alveoli. If there was more blood moving by quicker, you could get everything you inhaled into the blood. Immediately moves into blood: ventilation limited uptake, exercise = ventilation is higher, breathing more, perspire more. Alveoli are very delicate, don"t want them getting damaged. We have systems that will excrete and exclude certain sized particulates from areas of the lungs: greater than 5 microns will be blocked. Water breathers much more at risk due to higher uptakes fish -> water breathers.
