BISC 202 Lecture Notes - Lecture 32: Metaphase, Ploidy, Advanced Maternal Age

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Bisc202 lecture 32: chromosome mutations, large-scale changes (ii) Aneuploid = organism whose chromosome number differs from the wild type by part of the chromosome set. Generally the change is by one or a small # of chromosomes (can be more or fewer than normal) Monosomic = 2n-1 designation with 5 chromosomes. Trisomic = 2n+1 designation with 7 chromosomes. Most aneuploids arise from non-disjunction during mitosis or meiosis. Leads to aneuploid gametes which then fuse with haploid gametes at fertilization. Nondisjunction can occur in either in meiosis i or ii. If the nondisjunction occurs at the 1st division, the following cells are produced : If the nondisjunction occurs at the 2nd division, the following cells are produced: Based on the resulting genotypes, it can be determined whether the nondisjunction occurred at the 1st or 2nd division (meiosis i or ii) The missing chromosomes disturbs the normal gene balance.

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