PAT 20A/B Lecture Notes - Lecture 6: Insomnia, The Scientific World Journal, Coronary Artery Disease

• School: Ryerson University
• Department: Pathotherapeutics
• Course: PAT 20A/B
• Professor: Susan Bishop

Document Summary

Pat20 week 6: atherosclerosis: explain how pathophysiological processes result in the physiological changes to the vascular system resulting in atherosclerosis. Pat20 week 6: atherosclerosis: macrophages then change into foam cells filled with lipids --> plaque deposits --> stiffer artery walls, identify how the inflammatory process impacts on formation of atherosclerosis and thrombosis. Reference: profuso, e. , buttari, b. , saso, l. , capoano, r. , salvati, b. , & rigano, r. (2012). T lymphocyte autoreactivity in inflammatory mechanisms regulating atherosclerosis. The scientific world journal, 2012, 1-9: discuss the pathophysiological changes associated with the 4 stages atherosclerosis development, damage to endothelium. Results from tobacco use, hyperlipidemia, hypertension, diabetes, hyperhomocysteinemia (high levels of blood homocsysteine), infection. All of these cause a local inflammatory response. Note: c-reactive proteins (crp) (produced from liver) is a nonspecific marker of inflammation and it increases in many patients with coronary artery disease. Increased levels of crp are associated with unstable plaques, oxidation of ldls, cholesterol and increased uptake of macrophages.