PAT 20A/B Lecture Notes - Lecture 5: Hyperhomocysteinemia, Hyperaemia, Sympathetic Nervous System
2 Nov 2017
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Atherosclerosis: fo(cid:396)(cid:373)atio(cid:374) of the focal deposits of choleste(cid:396)ol a(cid:374)d lipids k(cid:374)ow(cid:374) as (cid:858)athe(cid:396)o(cid:373)as(cid:859) o(cid:396) pla(cid:395)ue, p(cid:396)i(cid:373)a(cid:396)ily within the intimal wall of arteries, that obstruct circulation (lewis 891) Largely characterized by focal deposits of cholesterol and lipids in the intimal layer of the artery. Non-modifiable risk factors: age, gender/sex, ethnicity: in south. Major: definitely associated with a significant increase in the risk of the development of cad (lewis 896: elevated serum lipid levels (ldl, hypertension ( bp >90-139/60-80, tobacco use (smoking, physical inactivity, obesity (abdominal) Contributing: associated with increased risk of cad, but their significance and prevalence have not been precisely determined (lewis 896: diabetes mellitus/ glucose intolerance, metabolic syndrome, homocysteine levels (by-product of methionine [aa] metabolism, elevated alcohol consumption. Endothelium layer (tunica intima) helps blood flow. Ii) muscular layer (tunica media) helps the pulse circulate blood: enables the artery to dilate or constrict.
