PAT 20A/B Lecture Notes - Lecture 12: Opioid Overdose, Vasodilation, Neutrophil

• School: Ryerson University
• Department: Pathotherapeutics
• Course: PAT 20A/B
• Professor: shirley

Document Summary

At cellular level (cid:224) o2 supply < demand: initial, not clinically apparent, metabolic changes are happening, aerobic and anaerobic changes cause lactic acid buildup(cid:224)anaerobic metabolism, decreased availability of cell energy (starving, development of lactic acid, death, liver unable to metabolize lactic acid due to lack of oxygen, compensatory, movement of fluid from interstitial to vascular spaces, activation of sympathetic nervous system, b adrenergic receptor stimulation. Increased respiratory rate and volume: metabolic acidosis (lactic acid build up) respiratory compensation, decreased urine output, water and na retention d/t decreased bp (renin angiotension) increases heart"s workload, progressive, massive sns compensation results in profound alpha adrenergic receptor stimulation and widespread vasoconstriction, refractory terminal, high mortality rate, cardiogenic: 50 90, septic: 35 50% Increased vascular resistance(cid:224)increased heart workload(cid:224)increase oxygen consumption: tachycardia, hypotension, narrow pulse pressure, tachypnea, pulmonary congestion bilateral crackles, peripheral hypoperfusion cyanosis, pallor, cool/clammy skin, long cap refill, decreased renal blood flow(cid:224)na and water retention(cid:224)decreased urine output, anxiety, confusion, agitation impaired cerebral perfusion.