PAT 20A/B Lecture Notes - Lecture 2: Pharmacogenomics, Morphine, Vascular Permeability
5 Oct 2018
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Document Summary
Phases of drug activity: pharmaceutics, pharmacokinetics, pharmacodynamics. Pharmaceutics: the science of preparing and dispensing drugs, including dosage form design (e. g. , tabs, capsules, injections, patches etc) (lilley, 2017, p. 23, process of turning a chemical into a medication. Pharmacokinetics: what the body does to the drug, kinetics = movement, four basic processes ( adme ), absorption, distribution, metabolism, excretion. Intensity of drug response: pharmacokinetics and pharmacodynamics are affected by individual variation, physiologic: age, sex, weight, pathophysiologic: kidney and liver function, genetic variability: lack of certain enzymes, drug interactions. Bioavailability: the proportion of the dose of a drug that reaches the systemic circulation after administration, best describes measurement of concentration in blood, factors that influence bioavailability, product preparations, routes of administration, first pass effect. Structure of the cell membrane: most drugs need to be able to penetrate membranes directly, to do this they must be lipid soluble & non-polar.
