ENH 220 Lecture Notes - Lecture 6: Disseminated Intravascular Coagulation, Von Willebrand Disease, Von Willebrand Factor

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Chapter 9- blood coagulation abnormalities and circulatory disturbances. Hemostasis: arrest of bleeding caused by activation of the blood coagulation mechanism, 5 factors concerned with hemostasis. Adequate amounts of calcium ions in the blood. Factors concerned with hemostasis: blood vessels and platelets. Small vessels are first line of defense in the body. Constrict on injury to facilitate closure by a clot (reflex vasoconstriction) Liberate vasoconstrictors and compounds causing platelets to aggregate. Blood coagulation process: highly complex chain reaction, phase 1: formation of thromboplastin by either interaction of. Intrinsic factors in blood (platelets and plasma factors) - plasma. Extrinsic factors from components outside circulatory system (tissue injury) - tissue: phase 2: conversion of prothrombin into thrombin. After thromboplastin interacts with additional plasma and platelet phospholipids, it splits prothrombin (made in liver) into several fragments: phase 3: conversion of fibrinogen into fibrin by thrombin. Thrombin splits off a part of the fibrinogen forms smaller molecules, fibrin monomers.

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