BLG 311 Lecture Notes - Lecture 5: Nuclear Transport, Leucine, Hydrophile
29 Dec 2017
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Document Summary
All proteins have a specific address or code on them that tell them where to go. A: because when they do not localize properly, it can lead to diseases like thes. These transporters that are involved in transport of sodium and protons. Nhe- na/h+ transporter has to be sorted and has to be found on the apical plasma membrane of a cell. In patients with thes, the nhe are not located on the apical membrane which can lead to this disease. For this particular disease the sorting machinery itself does not work, the address is fine and the protein is made it is just not going to the right location. Cell is organized in a series of compartments. Why compartmentalize the cell: to increase the surface area. Compartments give the cell more membrane surface area and biological processes occur closely to the membrane greater membrane area to cell volume ratio. More surface area for membrane-based processes: to segregate specialized functions.
