PHGY 214 Lecture Notes - Lecture 8: Androgen-Binding Protein, Granulosa Cell, Follicular Phase

• School: Queen's University
• Department: Physiology
• Course: PHGY 214
• Professor: Neil Magoski

Document Summary

Hypothalamus: gonadotropin releasing hormone (gnrh, 10 amino acids, identical in males and females. Anterior pituitary: luteinizing hormone (lh) and follicle stimulating hormone (fsh); gonadotropins. Testosterone, estrogen, progesterone: peptide hormone inhibin, gametogenesis. Spermatogenesis spermatigonium: outside of seminefrous tubule: divide and differentiate, but they don"t all differentiate, one daughter continues to replenish supply of sermatigonia, other one continues to divide till spermatozoa for each spermatodonium: 16 spermatozoa produced, 1 stays spermatogonia. Males continue to produce sperm throughout their life females will not. Female reproductive physiology same axis, but with ovary instead of testes dynamic changes of hormone secretion follicles, changes during menstrual cycle estrogen and: combination inhibits fsh, acts on granulosum cells. Diffuses accross basement membrane into granulosa cells. Under influence of fsh granulosa produce an enzyme called aromatase which converts androgen to estrogen. Fsh: stimulates granulosa cells, stimulates aromatase, estrogen in high in granulosa cells, causes further follicular cell perliforation. Prior to ovulation there is a surge in lh and fsh.