CHEM 281 Lecture Notes - C3D, Elemental Analysis, Combustion Analysis
5 Nov 2013
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Document Summary
Before used to have to use x-ray crystallography (make a crystal and then shine x-rays through) but now nmr: very sensitive type of question: Classic methods for organic structure determination: boiling point, refractive index. Functional group tests: derivative preparation, mixture melting point, combustion analysis: burning material and seeing what molecules are formed, degradation: heating up material and looking at fragments that come off. Sodium fusion (to identify n, cl, br, i & s) Classic methods for organic structure determination require large quantities of sample and are time consuming. Spectroscopic methods for organic structure determination: mass spectroscopy (ms, molecular mass & characteristic fragmentation pattern, infrared spectroscopy (ir) characteristic functional groups, ultraviolet spectroscopy (uv) characteristic chromophore, nuclear magnetic resonance (nmr) Spectroscopic methods for organic structure determination combination of these spectroscopic techniques provides a rapid, accurate and powerful tool for identification and structure elucidation of organic compounds rapid effective in mg and microgram quantities.
