BCHM 102 Lecture Notes - Lecture 30: Asparagine, Intron, Aminoacyl-Trna

• School: Queen's University
• Department: Biochemistry
• Course: BCHM 102
• Professor: Lauravan Staalduinen

Document Summary

Lecture objectives: understand role of protein translation in storage and expression of genetic information. Identify the genetic code and understand the relationship between genetic code and amino acid incorporation: mutations. Identify components required for and steps involved in translation: understand the role of post-translational modifications. P(cid:396)otei(cid:374) s(cid:455)(cid:374)thesis is (cid:272)alled t(cid:396)a(cid:374)slatio(cid:374) as the (cid:858)la(cid:374)guage(cid:859) of (cid:373) na is t(cid:396)a(cid:374)slated i(cid:374)to a(cid:373)i(cid:374)o a(cid:272)id (cid:858)la(cid:374)guage(cid:859) of protein. Info contained in dna sequence expressed as specific amino acid sequence: mutations in dna sequence may result in incorrect insertion of amino acids resulting in disease/death e. g. sickle cell anemia. Point mutation: altering a single nucleotide in mrna results in 1 of 3 effects: silent mutation: Codon containing changed base still codes for same amino acid: missense mutation: Codon containing changed base codes for a different amino acid: nonsense mutation: Codon containing changed base codes for termination codon.