ANAT 216 Lecture Notes - Lecture 2: Follicular Dendritic Cells, Reticular Fiber, Germinal Center
28 Apr 2018
School
Department
Course
Professor
ANAT 215 week 1 lecture 2
Lymphoid
organs
Lymphoid
organs
Diffuse lymphatic tissue (reticular CT, macrophages, lymphocytes) and follicles/nodules enclosed in dense
irregular CT capsule
Primary lymphatic organs: where stem cells divide and become immunocompetent, thymus + RB marrow
Lymph
nodes
(not an
organ bc
no
capsule)
Location= along path of lymphatic vessels, collection of lymph
nodes under skin in inguinal, cervical and axillary region
Function= filter lymph as it returns to the blood via macrophages,
B+T lymphocytes
Afferent lymphatic (lymph enters thru subscapular sinus)
trabecular sinus medullary sinus efferent lymphatic (lymph
exits found on concave side of node) reticular fiber in sinus trap
foreign sub
- Hilus: concave part where vessels enter/exit node
- Cells grab antigens until they are presented to B/T cells
Cortex: outer portion w dendritic and T cells, segregated by
extensions of capsule into follicles w germinal centers
Medulla: diffuse tissue continuation of cortex in medulla called
medullary cords, germinal center where B cells diff into plasma
cells and contains follicular dendritic cells + macrophages
Sinuses: cont series of spaces/channels
- Subscapular sinus: follows trabeculae (trabecular/corticol
sinus)
find more resources at oneclass.com
find more resources at oneclass.com
Document Summary
Lymph nodes (not an organ bc no capsule) Diffuse lymphatic tissue (reticular ct, macrophages, lymphocytes) and follicles/nodules enclosed in dense irregular ct capsule. Primary lymphatic organs: where stem cells divide and become immunocompetent, thymus + rb marrow. Location= along path of lymphatic vessels, collection of lymph nodes under skin in inguinal, cervical and axillary region. Function= filter lymph as it returns to the blood via macrophages, Afferent lymphatic (lymph enters thru subscapular sinus) trabecular sinus medullary sinus efferent lymphatic (lymph exits found on concave side of node) reticular fiber in sinus trap foreign sub. Hilus: concave part where vessels enter/exit node. Cells grab antigens until they are presented to b/t cells. Cortex: outer portion w dendritic and t cells, segregated by extensions of capsule into follicles w germinal centers. Medulla: diffuse tissue continuation of cortex in medulla called medullary cords, germinal center where b cells diff into plasma cells and contains follicular dendritic cells + macrophages.
