NURS 3012 Lecture Notes - Lecture 9: Respiratory Acidosis, Hypotension, Smooth Muscle Tissue
25 May 2017
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Document Summary
Asthma: asthma is a chronic, inflammatory, obstructive pulmonary disorder of the airways. Many cells play a role, including mast cells, eosinophils, and t-lymphocytes: three factors are responsible for airway narrowing, including: Inflammation inflammatory molecules react to an irritant or allergen, resulting in swelling, increasing mucous production and bronchoconstriction. This causes difficulty breathing and is the most important factor to try to manage. Bronchospasm excessive contraction/spasm of bronchial smooth muscle, leading to airway constriction and obstruction. Hyperactivity bronchial hyper responsiveness creates an exaggerated bronchoconstriction response to inhaled stimuli: the inflammatory response is important in understanding asthma. First, the inflammatory response occurs due to the presence of an allergen. Ige antibody is released and attaches to the antigen. Immune mast cells release inflammatory mediators (histamine, leukotriene) Smooth muscle spasms, increased mucous production & permeability of blood vessels allowing wbcs to enter bronchi. Ige antibody immunoglobulin e is an allergen specific antibody.
