NURS 2003 Lecture 9: Atherogenesis
20 Mar 2017
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Document Summary
Smooth muscle cells and collagen fibers migrate into tunica intima stiffen and thicken narrowed arterial lumen. Atherosclerosis- form of arteriosclerosis; caused by soft deposits of intra-arterial fat and fibrin that harden over time; can take several forms depending on location. Atherogenesis associated diseases: hypertension (htn, ischemic heart disease (ihd) Acute coronary syndrome (acs: myocardial infarction (mi, peripheral vascular disease (pvd, cerebrovascular disease. An inflammatory response of endothelial damage, where repair, the end stage of inflammation, causes a defect in the arterial wall. Tissue damage promotes platelet aggregation- platelets initiate a clotting cascade and blood clot forms. Inflammation initiated by platelet factors (serotonin) and pgs and damaged cm- cause an increase vascular permeability and attract macrophages to site (chemotaxis) Macrophages: destroy damaged cells; secrete chemicals that promote growth of new cells (e. g. fibroblasts) With atherogenesis this is occurring in the vascular endothelium. Stages of atherogenesis: damaged endothelium, fatty streak, fibrous plaque, complicated lesion. Physical build up of plaque leads to occlusion.
