NURS 2003 Lecture Notes - Lecture 7: Hypotension, Paracetamol, Phagocytosis
20 Mar 2017
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Document Summary
Occurs due to a breach in first line of defense. Not a patho change but commonly associated with a number of conditions: Antibody activity: ige (allergic reaction, ag-ab complexes (igg, igm, iga) Prostaglandins (pgs) and leukotrienes (lt: synthesized, damaged cell membranes. Serotonin (5-ht: released, mast cells (tissue) or basophils (blood) Released from mast cells and basophils (circulating and activated by c"): degranulation. Platelets activated when collagen is exposed by damage to blood vessel walls. From mast cell de granulation or injury to cm. Arachidonic acid synthesizes pg and lt (our focus is pg but remember lt do same) By ag-ab complexes (iga, igg, igm, but not ige) Multiple c" fragments have activity- consider just as c", don"t worry which. Poke holes (pores) in cm- allows h2o ions to enter cell- cell lysis. Duration of mast cells or basophils (which then release histamine) Pg more likely important than h1! (histamine usually only starts the process)
