PSYC 2275 Lecture 7: PSYC 2275 - Lecture 7 - The Chemistry of Behaviour (Serotonin, Glutamate and GABA)
7 Oct 2016
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Psyc 2275 - lecture 7 - the chemistry of behaviour (serotonin, glutamate and gaba) Most serotonergic neurons are located in the raphe nuclei (collections of neurons located throughout the brainstem) Has been implicated in sleep, mood, appetite, aggression, sexual behaviour, anxiety, etc. 5-ht agonists: lsd (acid) and psilocybin (magic mushrooms) are agonists at the 5-ht2a receptors. Distort visual perceptions and other effects: mdma (ecstasy) increases 5-ht and da levels by reversing transporters. Elevates 5-ht signaling (includes mao inhibitors like marplan) and selective serotonin reuptake inhibitors (ssri"s like prozac) that block 5- Glutamate: major excitatory neurotransmitter in the central nervous system; most brain activity results from glutamate signaling. Gaba: major inhibitory neurotransmitter in the central nervous system; is responsible for many ipsps in the brain, inhibition is important in brain function. Ionotropic and metabotropic receptors: ionotropic: ampa, nmda, kainate receptors, binding results in opening of sodium ion channel, activation of metabotropic can be excitatory or inhibitory.
