PSYC 3030 Lecture Notes - Lecture 13: 5-Ht3 Receptor, Raphe Nuclei, Chemical Synapse
12 Nov 2016
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Document Summary
Most 5-ht cell groups are associated with the raphe nuclei and the reticular region of the lower brain stem. The largest cluster of 5ht neurons is found in the dorsal raphe nuclei. B1-b4, located in the medial regions of the medulla and caudal pons, project to the spinal cord and cerebellum and regulate sensory, motor, and automatic functions. Inhibition of pain signals from the spinal cord. B2 and b1 also descend down the spinal cord. Some are in the prime position to influence incoming information from the spinal cord. B5-b9, associated with raphe nuclei of the rostral pons and mesencephalon as well as with the caudal linear nucleus, nucleus pontis oralis, and the supralemniscal region (b9) 80% of all forebrain 5ht originates from the dorsal (b6/7) and median (b5/8) raphe. There are two distinct ascending 5ht projections: ventral and dorsal pathways. Tectum in the superior colliculus is important for visual orientation.
