PSYCH 2AP3 Lecture Notes - Lecture 11: Endophenotype, Candidate Gene, Dopamine Receptor D4
30 Jan 2017
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Adhd runs in families - more for girls than boys. Heritability based on parent"s ratings . 6-. 9 (less for teacher ratings - . 4-. 6) Candidate gene approach: search for link between theoretically interesting genes and disorder - most common approach. Whole-genome scan: search entire genome for promising areas - narrowing it down to chromosomal area. Two whole genome scan studies: looking for broad areas that were different: 5p12, 10p26, 12p23, 16p13, 7p13, 9p33, 15p15 - first number is a chromosome, p arm is short arm, q is the long arm of chromosome. Two candidate genes: dat1 - dopamine transporter gene chr5, drd4 -dopamine d4 receptor gene chr 11. Genes --> brain structure --> attention --> disorder symptoms --> phenotype. -> brain chemistry --> response inhibition ---disorder symptoms -phenotype. -> working memory --> disorder symptoms --> phenotype. -> endophenotype as well as from working memory. Can study people without disorder, but with same endophenotype.
