MEDRADSC 2X03 Lecture Notes - Lecture 12: Acute Radiation Syndrome, Total Body Irradiation, Prodrome

• School: McMaster University
• Department: Medical Radiation Sciences
• Course: MEDRADSC 2X03
• Professor: Sandra Charbonneau

Document Summary

Ars - acute radiation syndrome: what happens w large single doses of radiation (usually unintentional, syndrome. Relationship of specific signs and symptoms to specific type of trauma or disease: ars is a combined response of multiple body systems, requirements. Total body irradiation over period of minutes. External penetrating radiation source (not internal to the body: brachytherapy doesn"t count. Primary effect is shortened lifespan ("early radiation lethality": survival time and mode of death depend on dose, for given dose, survival time varies depending on individual radiosensitivity, pt age, general health. For humans: ld(50/60, ld - lethal dose, first number (50) - % of population will die, second number (60) - how many days, 2. 5 - 3 gy without treatment, 4 - 6 gy with medical treatment. Stages of response of ars: prodromal syndrome, omg it just happened. Latent period: body needs to figure out what just happened, manifest illness, the body"s reaction, able to repair.