HTHSCI 2H03 Lecture 2: Drug Distribution, Metabolism, and Elimination Notes
20 Sep 2018
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Distribution are nonpolar diffuse across plasma membranes and are absorbed into the b ood. Drugs that are nonpolar are also easily distributed through body tissues. Only free drug molecules can be distributed into body tissues. I solubility ) of the drug dictate distribution. Blood brain barrier can be a problem certain drugs wont be hook fetal placenta barrier. + not interfere baby harm a co kinetics first f hilt. Cant take aspirin t warfarin simultaneously it drug is really fat soluble it will leave vasculature t enter cells ( t fat distribution easily lol u ble - Distribution \ parenteral administration drugs distribute to target tissues and exert a biological. I therapeutic effect oral administration drugs are first distributed to the liver via the hepatic portal circuit. A fraction of the dose is metabolized first pass liver then circulation effect and no response longer theres available to exert a biological drug loss w/ metabolism in liver yr.
