BIOLOGY 2C03 Lecture 3: Week 3 - Regulation of Gene Expression
23 Sep 2017
School
Department
Course
Professor
Document Summary
Dna methylation: results in gene silencing and inhibits transcription in two ways: directly - binds to cpg islands and inhibits binding of activator protein, indirectly - other proteins recruited to close convert chromatin to closed conformation. X-chromosome inactivation turns o expression from one x chromosome inactivation regulated by incrna interacts with histone modi cation and dna methylation enzymes. X-inactivation-speci c-transcript (xist) the xist rna covers the inactivated x chromosome and this attracts proteins that modify the structure of the chromatin (making it compact, thus inactive) ***review this. Fall 2017 (cid:131) transcription activators and repressors = transcriptional factors (trans-acting) (cid:131) regulatory dna sequences: (cis-acting) (cid:131) core promoter region (tata box) (cid:131) enhancer and silencer sequences. Regulating gene expression at the level of transcription often comes down to whether activators, inhibitors and/or other dna binding proteins can access the dna. Activating transcription requires an open promoter that is accessible to proteins:
