BIOLOGY 2B03 Lecture Notes - Lecture 9: Proteasome, Cdc20, Cytokinesis

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11 Dec 2015
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Single cell cycle can be divided into 4 events. G1 (1st gap phase): cell is growing, engaged in gene expression and the synthesis of new proteins. S-phase (dna synthesis phase): cell is ready to divide, replicates genome: single chromosome contains two identical copies replicated sister chromatids. Mitosis (m-phase): replicated sister chromatids separated to two daughter cells. Cell cycle is highly regulated, so there is an alteration between dna replication and cell division: coordinated with the growth of the cell, failure for regulation leads to cell death or over-proliferation. G0 (g-nought): quiescent state, where division does not occur. Cells exit the cell cycle and enter g0. After differentiation, the cell is no longer capable of cell division. M phase can be further divided into phases. Interphase (g1 s g2): prepares for mitosis, chromosomes, and associated proteins are replicated in s-phase, centrosomes are duplicated in.

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