BIOLOGY 1M03 Lecture Notes - Lecture 21: Haplotype, Heterozygote Advantage, Overdominance

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1 Apr 2016
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What are the implications of variation? (cid:1) (cid:1) (cid:1) (cid:1) (allele x is found in people with trait y) (allele x produces a protein that does z) (allele x is more variable in location b) (allele x is found in an selected region) (cid:1) (cid:1) Haplotype: non-recombining dna (piece of genome that is inherited as a unit) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) Fitness depends on : alternative alleles, genetic background (epistasis or gene by gene interaction) Epistasis: gene only has a particular effect in presence of another gene: environment (gene by environment interaction) Phenylketonuria inability to process this no problem if you don"t consume aspartame but if you are in an environment that you do it then there is a problem (only deleterious under certain environment) Note : you can choose your own environment! Over-dominant selection: might be an advantage to being a heterozygote with this allele.

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