BIOLOGY 1M03 Lecture 2: Bolker Lecture 2 almost test updated
18 Oct 2015
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Document Summary
Questions what maintains deleterious alleles in the face of natural selection? what creates and maintains genetic diversity? what maintains geographic variation? what are the implications of variation? blah mutation drift (finite populations) selection migration non random mating. Evidence for history and function of genes gene trait associations (allele x is found in people with trait y) mechanistic arguments (allele x produces a protein that does z) gene environment associations (allele x is found in environment a) geographic variation in diversity (age) (allele x is more variable in location b) haplotype patterns (age) (allele x is found in an selected region) Mutation/selection balance purifying selection vs. deleterious genes dominant ( m/s ), recessive ( m/s ) e. g. m=10 4 , s=0. 5. 0. 02% or 1. 4% achondroplasia rate 1/25,000 m 10 5. Sickle-cell overdominance (heterozygote advantage) selection for falciparum malaria resistance geographic patterns; consistency with malaria distribution mechanistic basis for protection evidence for positive selection (age??)
