BIOLOGY 1A03 Lecture Notes - Lecture 2: Francis Collins, Lumacaftor, Osmosis

• School: McMaster University
• Department: Biology
• Course: BIOLOGY 1A03
• Professor: Lovaye Kajiura

Document Summary

The most common fatal genetic disease (1/3,600 children born in canada) A hereditary disorder affecting the exocrine glands. It causes the production of abnormally thick mucus, leading to the blockage of the pancreatic ducts, intestines, and bronchi and often resulting in respiratory infection. Many effects on the body, but mostly affects digestion and lungs. With chronic persistence and bacterial infections, destruction of lungs leads to the move prevalent cause of death. Current life expectancy of someone with cystic. Goblet cells secrete mucus which traps any dust particles and bacteria. Cilia motility and cilia generated ow push mucus up and out of the trachea. Airway surface liquid should have adequate volume to allow rhythmic ciliary beating and allow for mucociliary transport. The cftr gene was discovered in 1989 at the sick kids hospital (toronto) by francis collins, The cftr gene is expressed on the long arm of chromosome 7. Translation via er-bound ribosomes; folding chaperone assistance.