PHGY 209 Lecture Notes - Lecture 12: Cancer Immunotherapy, Ctla-4, Cd28
21 Feb 2018
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Innate immune response (how it introduces the immune system to the bacteria) Class i on all cells; class ii only on apcs (macrophage, b cell, dendritic cell: dc is professional because it has two stages of life cycle (phagocytotic stage, and synthetic) Origin of b cell (bursa of chicken, bone marrow) Origin of t cell (bone marrow to the thymus as pre-t cells which are matured in the thymus where 95% of cells die) 95% of death = self-recognition t cells. The mechanism of identifying self-recognition t cells is unknown. How liver ag are seen in the thymus in utero is also unknown. However, there is a hypothesis that the endothelium of the thymus can produce all other body ag (unlikely, but possible). This identification step is crucial to ensuring that the immune system will not attack itself. With time t cells arise in the thymus in adult life which also have to be monitored (called peripheral tolerance).
