PHGY 209 Lecture Notes - Lecture 4: Immune Tolerance, Immunoglobulin Light Chain, Thrombolysis
17 Mar 2017
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Skid: severe combined immune deficiency: if you do an autopsy on a kid, you"ll find, no thymus gland, bone marrow abnormal, no lymph nodes. Primary organs: (stem cells from the yolk sac and fetal liver, bone marrow, thymus gland. Seondary organs (happens before birth: lymph nodes, spleen, mucosa-associated lymphoid tissues (malt) Terms: antigen, immunogen, hapten (+ carrier = immunogen, allergen, tolerogen, a material is seen as foreign, but not reactant against, ex: our bodies will not, ligand, if it binds to an antibody. Three lines of defenses: the coverings of the body (skin and mucus membrane), skin and. The innate immune response: early in evolution, danger signals, has no memory, not specific. The innate immune response: results in inflammation, 4 classical signs, rubor (redness, calor (heat, dulor (pain, tumor (swelling, cellular response, the tissue macrophage, recognition of bacterial pathogen associated molecular (membrane) Now called t-cells: only 5% of cells will leave thymus.
