PHGY 209 Lecture Notes - Lecture 12: Cd28, Cancer Immunotherapy, In Utero

• School: McGill University
• Department: Physiology
• Course: PHGY 209
• Professor: Alvin Shrier

Document Summary

There are both humoral and cellular factors in humoral and cell-mediated. All cells in the body have a mhc class 1 molecule. If it is modified by a viral infection or cancer, the natural killer will destroy that cell. In humans, it"s called hla human leukocytes antigens. Molecules against which a graph projection takes place. Hla antigens that are the area where the initiation of the immune response occurs. 2 molecular classes: mhc 1 (hl-a, hla-b, hla-c) all cells in body have them, mhc 2 (hla-dp, hla-dq, hla-dr) All cells in the body have class 1 molecule. Class 1 molecule becomes the target for killing. Only 3 cells in the body have class 2: dendritic cell, macrophage, b lymphocyte (b cell) The bug is sitting in a vacuole and it makes mhc class 2 molecule. After the molecule is done being digested and broken down. Dendritic cell: does things faster and the most efficiently.