PHGY 209 Lecture Notes - Lecture 2: Phosphorylation, Cytosol, Endothelium

• School: McGill University
• Department: Physiology
• Course: PHGY 209
• Professor: Ann Wechsler

Document Summary

Transport mechanisms: viability of cells depend on relative constancy of internal environment, so requires exchanges between internal & external environment, 28l/42l (majority) in intracellular fluid --cell membrane is semipermeable (between. Icf and isf: other barrier, capillary wall, between plasma and isf, lungs, skin, kidneys and gi tract also involved in movement of material, cell membrane is around cell, and also around organelles: nucleus, endoplasmic reticulum, etc. Cell membrane: function: support distinct composition of icf and isf, and be selectively permeable, highly permeable to, water, lipid-soluble substances, dissolved gases (o2/co2, small uncharged molecules, less permeable to, larger molecules, charged particles. Inserted in phospholipid layer, in between hydrophobic tails. Functions of plasma membrane proteins: selective transport channel (transport molecules into/out of cell, enzyme (catalyze membrane associated reactions, cell surface receptor (receiving transducing chemical signals from cell environment, cell surface identity maker, cell adhesion, attachment to cytoskeleton.