PHAR 505 Lecture Notes - Lecture 11: Tetrahedral Carbonyl Addition Compound, Hiv-1 Protease, Reaction Intermediate
23 Nov 2017
School
Department
Course
Professor
Document Summary
Phar 505 lecture 11 (10/10/2017) by: r. akong. **this lecture is particularly heavy in concepts that prof thinks we need to understand. **the questions on the exam will depend heavily on understanding (rather than regurgitating) this material. The arrange for a chemical reaction to happen rapidly and/or quickly when it would not normally take place or would take place over a very long time. If it wasn"t for an enzyme, the first reaction would take 78 000. The enzyme allows the reaction to take place in a timeframe that is reasonable. The enzyme is the catalyst: pre-organise the molecules in a way that they will react and can do what they have to do. This is an energy diagram but it is missing 2 crucial things: y-axis = energy, x-axis = reaction coordinate. For each step, you need to go up in energy in order to transform into the final product. It doesn"t exist for any finite amount of time.
