PHAR 505 Lecture Notes - Lecture 2: Cell Nucleus, Acylation, Beta Barrel
12 Oct 2017
School
Department
Course
Professor
Document Summary
Enzymatic catalysis ie. hiv protease target molecule: the structure stabilises the transition state (ts) of a chemical reaction thus accelerating the reaction. Signal transduction switch (ras in gtp or gdp-bound form: protein switches structure under different conditions, thus sensing the state of the cell. Structural proteins ie. keratin, actin filaments: the protein structure confers mechanical strength or specific architecture through formation of networks, scaffolding, ecm, these proteins adopt predictable structures. Tbp tf bound to tata box, hiv protease bound to substrate and ras in mg-gtp bound form. Proteins are made of 20 different types of aas. An aa is made of an amino group, carboxylic acid and a variable r group. These groups are attached to the carbon alpha with tetrahedral geometry. Tetrahedral c : amino group + r group (side chain) indicates the identity of the aa + acid group, chiral centre. Most natural aas in proteins are formed by the l-stereoisomer.
