PARA 438 Lecture Notes - Lecture 11: Immunogenicity, Mhc Class Ii, Mhc Class I
25 Oct 2018
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On surface protein, at against surface protein, make them able to attach it. Cd3: goes intracellularly, it can activate all other t cell. Too strong interaction with self; already interacting, but too strong. Are recognizing self, at the just right amount of threshold. Don"t need to know details about tables (have label for it) Not all ags are immunogenic by adaptive immunity. Low immunogenic ag will be taken care by innate immunity and not go to adaptive, usually it will not create a memory. Ag get to adaptive immunity is highly immunogenic. The one that can get into adaptive immunity is with the help of adjuven + have memory [immunogenicity] Native t cell presented by ag that can differentiate into diff effector cell. Many system is autocrine and cytokine, another part is the cross regulation. There are many other mechanisms, some promote sequence into one or another.
