PARA 438 Lecture Notes - Lecture 2: Cfu-Gemm, Programmed Cell Death, Hematopoietic Stem Cell
25 Oct 2018
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Sep. 10 cells & lymphoid organs of immune ststem. B cells --->immature thymocyte-->becomes t helper cell -->tc-->t reg (needed to regulate all others t cells) Monocyte, dendritic, macrophage: ag presenting cell (present to t cells) Common lymphoid progenitor produces (after encounter ag . Hematopoietic stem cells: (how they produced + developed) All three can be found in bld and lymph nodes. Common myeloid progenitor: become granulocyte/ macrophage progeniter. Derived from both lymphoid progenitor + myeloid progenitor. Male: 4. 7-6. 1m cells of bld female: 4. 2-5. 1 m cells of bld. Control levels + types of cytokines produced by bone-marrow stroma cells. Apoptosis embryogenesis (shaping adult forms limb) to suppress vestigial embryonic structure eliminating (self-reacting lymphocytes ) Blebbing (bulge / protrusion of plasma membrane; decouplingof cytoskeleton) Programmed cell death: (things that you don"t need) Will have inflammation due to released cytokines, neutrophils, wbc and etc. Regulate normal life span of various hematopoietic cell. Activated b increases cytokine r number + decrease bcl-2 gene.
