NSCI 201 Lecture Notes - Lecture 8: Retinal Ganglion Cell, Amacrine Cell, Ganglion Cell

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Light enters the eye by travelling through all layers of the retina. Changes in signaling from the bipolar cells changes the potential of retinal ganglion cells, which fire aps when excited. 5 classes: photoreceptors (prs) convert light input into a neural signal. Horizontal cells (hcs) modulate pr signals to bipolar cells (bcs) Negative feedback loops to the synapse: bipolar cells pass photoreceptor signals onto ganglion cells (gcs) Amacrine cells modulate bc signals that are passed to gcs: ganglion cells receive bc (excitatory) and ac (inhibitory) signals and generate action potentials that leave the retina via the optic nerve. There are sub-classes of cell types that have different shapes and functions: divide visual input into features (ex: some respond better to contrast) Split the visual input into parallel on and off channels to detect brightening and dimming: bipolar cell bodies reside in the inner nuclear layer, bipolar cell axon terminals reside in the inner plexiform layer.

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