MIMM 214 Lecture Notes - Lecture 10: Integrin, Selectin, Chemokine Receptor
7 Jun 2018
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Lecture 10 – January 25, 2017
Linking Innate and Adaptive Immunity
Traveling to lymphoid tissues and visualizing antigen presentation
DCs travel from site of infection to lymphoid tissue
Homing to lymph node
- DCs travel via lymphatic vessel
- DCs express receptors that target them to lymphoid tissue
Antigen presentation
- Activation of CD4 (Th) and CD8 (Tc) T cells
- 3 signals
- Signal 1
o MHC:TCR
- Signal 2
o B7:CD28
- Signal 3
o Cytokines
APCs activate T cells through 3 crucial signals
- Three signals needed to activate T cells
- Activation – pMHC:TCR
- Survival – costimulation
- Differentiation – Cytokines
Dendritic cells travel to lymph nodes
Activated DC travels to lymph node
- Activated DC migrates through lymphatic vessel to reach lymph node
Lymphoid tissues iclude: lyph odes, splee, Peyer’s Patch
Lymph node
- DCs enter lymph node via afferent lymphatics
- Note that T and B cells enter through High Endothelial Venules (HEV)
- Zones within lymph node where T and cells hone to
- Activated DCs loaded with Ag enter lymph node
- They can transfer antigen to resident DCs
o Depends on which MHC (I or II) you want to use
o For amplification of response
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