MIMM 214 Lecture Notes - Lecture 23: Interleukin 4, Interleukin 21, Phases Of Clinical Research
15 Mar 2017
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Research at mcgill: they studied the immune response to zika virus in a mouse model, zika virus is transmitted via mosquito bite; ongoing epidemic in the americas particularly in south. Figure (1) represents the relative expression of t-bet in cd4+ cells. In response to tgf-beta, il-6, and il-23 (signal 3: characterized by production of il-17 (primary effector cytokine, master transcriptional regulator: ror-gammat, discovered in 2005! Th17: signal 3 and effector cytokine: the cytokines that impact the differentiation of na ve t cells into th17 cells: tgf-beta, il-6, il-23, the cytokines that are produced by effector t cells: il-17 and il-22. Th17: signaling and master transcriptional regulator: signal 3 which consists of tgf-beta, il-6, and. Il-23, signals through stat proteins, which will prompt the t cell to differentiate and express the master transcriptional regulator, Ror-gammat which will induce transcription of various effector genes of th17 including il-
