MIMM 214 Lecture 23: Adaptive Immunity VI: TH17 Cells and Intro to Tfh Cells
6 Mar 2017
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Recent research findings: mice were either infected with zika virus (zikv) or mock infected (i. e. not infected) Figure i represents the relative expression of t-bet in cd4+ cells. Tf --> new tf: stat3 --> ror t, new tf --> t cell subtype, ror t --> th17. Secrete il-17: stimulates stromal cells to secrete more cytokines. Impact on epithelial cells to produce antimicrobial peptides: recruits neutrophils, aid in targeting extracellular bacteria and fungi. This is meant to illustrate the scientific process & that much remains unknown. Th17 responses are involved in a number of inflammatory disease, including autoimmune disease and allergy: psoriasis. Inflammatory bowel disease: asthma, rheumatoid arthritis, multiple sclerosis. Therapies targeting il-17 are currently being studied and some have already been approved for clinical use. Th17 responses to infection: effects mainly in mucosal surfaces, doesn"t bind directly to mhc ii on target cells. Il-17 and il-22 can induce epithelial cells directly to produce antimicrobial peptides: can contribute to killing/slowing bacteria.
