MIMM 214 Lecture Notes - Lecture 6: Antigen, Cd31, Opsonin
15 Mar 2017
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Document Summary
Innate immunity has 3 types of phagocytes: macrophages, dendritic cells (immature/mature), neutrophils (and other granulocytes) Saliva, hair, mucus, tears are all elements that provide innate immunity. Mature dcs can produce large amts of cytokines. Mature dcs include: conventional dcs & plasmacytoid dcs. Migration of innate cells to site of infection. Recruitment of leukocytes (monocytes & neutrophils) to site of infection leads to inflammation, and eventually loss of function; this prevents the antigen from further spreading into the peripheral tissues. Recruitment is done by adhesion molecules (diff. adhesion molecules on different tissues; target immune cells to different places, tell your immune cells where to go) As monocyte rolls it can bind to the chemokine (produced in response to antigen). This tight binding causes migration of the monocyte across the vascular membrane, into the infection site. Pathogens bind to receptors on the cell surface of phagocytes, then become engulfed.
