BIOC 311 Lecture Notes - Lecture 29: Hepatocyte Nuclear Factor 4, Prmt1, Enterohepatic Circulation

• School: McGill University
• Department: Biochemistry
• Course: BIOC 311
• Professor: Maxime Denis

Document Summary

Upstream signal action dictating nuclear receptor activity (hnf4 ) These receptors are heterodimeric (2 different subunits), that contain a central zone: central zones incorporate the dbd, lbd, and end region (hinge of downstream sub. , they are responsible for coordinating the activity of each of these regions. Phosphorylation of s78: this disrupts the attraction between the dna and dbd since it is so closely beside the lbd. It compromises the integrity of the receptor folds, where the dbd is unable to available for dna to bind well. Mutations in the lbd provoke a clash in the central region that decreases binding affinity of. Dna to the dbd sites allowing for the development of diabetes. Germ-line mutations in tfs result in disease. Fxr connections: bile acid metabolism is controlled by nuclear receptors. Bile acids (ba) are sterol acids, which form micelles to help digest lipids.