BIOC 311 Lecture Notes - Lecture 2: Leucine Zipper, Dna-Binding Domain, Peroxisome Proliferator-Activated Receptor
3 Dec 2016
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Document Summary
Transcriptional control of metabolism - metabolic regulation in complex organisms. Disturbance of energy homeostasis = contribute to etiology of many diseases - heart. A- short term regulation - quick = secs/mins. Under hormonal control *catecholamines & achieved through: allosteric control of key enzymes, post-translational modifications of key enzymes. B- long term regulation - slow = hrs/circadian cycle/seasons-diff weight/development/aging: requires transcriptional regulation of metabolic genes that express key enzymes. Most metabolic regulations = benefit from coordination of these 2 main types of control mechanisms: allosteric control. Transcriptional control of metabolism responses: post-translational modifications, transcriptional gene regulation. Transcriptional control need to target specific signals to be transduced to cell nucleus where gene. Define signals involved - glucagon/glucocorticoids & route to nucleus = activated by signaling. * transcription factor = no enzymatic activity & only work through co-regulators for gene. Regulate gene expression = enzymatic activity of co-regulators. Expression of metabolic enzymes/direct effect or cascade of regulators.
