BIOC 311 Lecture Notes - Lecture 10: Acetyl-Coa, Oxidative Phosphorylation, Oxaloacetic Acid

• School: McGill University
• Department: Biochemistry
• Course: BIOC 311
• Professor: Maxime Denis

Document Summary

Citric acid cycle: is a series of 8 enzymatic reactions that occur within the inner mitochondrial matrix. Goal is to combine 2 mol. of acetyl-coa with oxaloacetate to generate co2, Since oxaloacetate is a coenzyme, it gets regenerated at the end of the cycle. Supports oxidative phosphorylation (i. e. : it is an aerobic process), but does not consume o2 directly. 3nad+ + fad + gtp + pi + acetyl-coa 3nadh + fadh2 + gtp + coa + 2co2. 3 main functions of cac: oxidation of acetyl-coa, formation of nadh + fadh2, making intermediates for other biosynthetic processes. It does through nadh reduction equivalence and through high energy ester bonds (transforming. Succinyl-coa 2 components ( , : (suckla2) generates atp directly (brown fat lipocytes, (suckle2) gtp formation. Cac: combine acetyl-coa (2c) with acetate (4c) to make citrate (6c) Co2 comes from oxaloacetate (the carbons come from oxaloacetate, not acetyl-